Care Global Pharmacy

Pradaxa (Dabigatran Etexilate Mesilate) 150mg Capsules contain dabigatran etexilate, which is an oral anticoagulant used to prevent and treat blood clots. It works by inhibiting thrombin, a key enzyme in the blood clotting process, thereby reducing the risk of clot formation.

Key Uses of Pradaxa (Dabigatran Etexilate) 150mg Capsules:

1. Prevention of Stroke and Systemic Embolism in Atrial Fibrillation:

   • Dabigatran is commonly prescribed for people with non-valvular atrial fibrillation (AF), an irregular heart rhythm that increases the risk of stroke and blood clots. By inhibiting thrombin, it helps reduce the likelihood of clot formation and lowers the risk of stroke or systemic embolism.

2. Treatment and Prevention of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE):

   • Dabigatran is used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE), which are conditions caused by abnormal clotting. It also helps prevent the recurrence of these conditions once treated.

3. Prevention of Venous Thromboembolism (VTE) After Surgery:

   • Pradaxa is often used to prevent venous thromboembolism (VTE), which includes DVT and PE, in patients undergoing hip or knee replacement surgery, where there is an increased risk of clot formation due to surgery and immobility.

4. Prevention of Blood Clots in Certain Cardiac Procedures:

   • In some cases, dabigatran is used in combination with other treatments for patients who undergo cardiac procedures like catheter ablation or cardioversion, which may increase the risk of blood clots.

Mechanism of Action:

Dabigatran is a direct thrombin inhibitor. By inhibiting thrombin, which is a critical enzyme in the blood clotting cascade, it prevents the conversion of fibrinogen to fibrin, a key step in blood clot formation.

Important Considerations:

• Bleeding Risk: As an anticoagulant, Pradaxa increases the risk of bleeding, which can be serious or life-threatening. Patients should be monitored for signs of bleeding, and dosage adjustments may be needed in case of kidney dysfunction.
• Kidney Function: Dabigatran should be used cautiously in patients with impaired kidney function, as the drug is eliminated through the kidneys. Regular monitoring of kidney function is necessary.
• Discontinuation: If surgery or invasive procedures are planned, Pradaxa may need to be stopped for a period of time to reduce the risk of bleeding.
• No Routine Monitoring Required: Unlike some other anticoagulants (like warfarin), dabigatran generally does not require routine blood monitoring (e.g., INR), but patients should still follow healthcare provider recommendations regarding timing and dosage.