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Nikoran Nicorandil 5mg Tablets contain nicorandil, a medication used primarily to treat certain heart conditions, particularly angina. Nicorandil works by relaxing and widening blood vessels, which helps improve blood flow and reduces the heart's workload.

Key Uses of Nikoran Nicorandil 5mg Tablets:

1. Angina Pectoris (Chest Pain):

   • Nicorandil is primarily used to treat stable angina (chest pain caused by narrowed coronary arteries) and unstable angina. It works by dilating blood vessels, improving oxygen supply to the heart, and reducing the heart's oxygen demand, thus helping to prevent and reduce episodes of chest pain.

2. Preventing Angina Attacks:

   • Nicorandil helps prevent the occurrence of angina attacks in people who have coronary artery disease (CAD), where the heart's blood supply is restricted, often leading to chest pain.

3. Heart Failure:

   • In some cases, nicorandil is used as an adjunct therapy in heart failure to help improve blood flow and reduce the workload on the heart.

Mechanism of Action:

Nicorandil works through two mechanisms:

• Potassium Channel Activation: It activates potassium channels in smooth muscle cells, leading to the relaxation of blood vessels.
• Nitrate-like Effect: It also has a nitrate-like effect, which further dilates blood vessels, especially veins, reducing the amount of work the heart has to do.

Important Considerations:

• Side Effects: Common side effects include headache, dizziness, flushing, and nausea. These occur because of the vasodilation effect of the medication.
• Contraindications: Nicorandil is not recommended for people with severe hypotension (low blood pressure), severe heart failure, or those with a history of certain heart conditions. It should also be avoided in patients who are allergic to the drug or have issues with potassium levels.
• Care with Other Medications: It should be used with caution in combination with other blood pressure-lowering drugs and certain medications for erectile dysfunction (like sildenafil).

Always follow the prescribed dosage and instructions from your healthcare provider to ensure the safe and effective use of Nikoran Nicorandil.

Dilzem 30 Tablet CR is used to treat angina (heart-related chest pain), high blood pressure, and some types of irregular heartbeats (arrhythmia). It is known as a calcium channel blocker. It works by relaxing blood vessels to lower blood pressure. This helps to reduce the workload of the heart.

Sorbitrate Isosorbide Dinitrate 10mg Tablets contain isosorbide dinitrate, a medication that is used primarily to manage and treat heart-related conditions. It belongs to a class of drugs known as nitrates, which work by relaxing and dilating the blood vessels to improve blood flow and reduce the heart's workload.

Key uses of Sorbitrate Isosorbide Dinitrate 10mg Tablets:

1. Angina Pectoris (Chest Pain): Isosorbide dinitrate is commonly used to prevent and treat angina pectoris (chest pain) associated with coronary artery disease (CAD). It helps by relaxing and widening the blood vessels, improving blood supply to the heart muscle, and reducing the frequency and severity of chest pain.

2. Heart Failure: It can be used to treat heart failure in combination with other medications. By dilating blood vessels, it reduces the amount of work the heart needs to do to pump blood, which can help relieve symptoms of heart failure.

3. Prevention of Angina Attacks: It is often used as a long-term treatment for preventing episodes of angina, particularly in people who have chronic angina and are at risk of frequent chest pain.

Mechanism of Action:

Isosorbide dinitrate works by releasing nitric oxide, which relaxes smooth muscles in the blood vessel walls, leading to vasodilation (widening of the blood vessels). This helps lower blood pressure, reduces the heart's workload, and increases oxygen supply to the heart.

Important Considerations:

• Tolerance: Over time, the body can develop a tolerance to nitrates. To avoid this, the medication is often taken in a way that includes a "nitrate-free" period during the day (such as avoiding continuous use).
• Side Effects: Common side effects may include headaches, dizziness, and low blood pressure, especially when standing up quickly. It's important to take this medication as prescribed.
• Drug Interactions: Isosorbide dinitrate should not be used with certain medications, especially PDE5 inhibitors (such as sildenafil, used for erectile dysfunction), as this combination can cause dangerously low blood pressure.

As always, it's important to follow the healthcare provider's instructions regarding dosage and to report any side effects or concerns.

7.5mg Coralan Ivabradine Tablets contain ivabradine, a medication primarily used to treat certain heart conditions. Ivabradine works by reducing the heart rate, making it useful in conditions where controlling the heart rate is important for managing symptoms and preventing complications.

Key uses of Coralan Ivabradine 7.5mg Tablets:

1. Chronic Heart Failure (CHF): Ivabradine is used to manage chronic heart failure in patients who have a heart rate above a certain threshold (usually greater than 70 beats per minute), particularly when other treatments such as beta-blockers are not well tolerated or are not sufficient. By lowering the heart rate, it helps reduce the heart's workload and improves symptoms such as shortness of breath and fatigue.

2. Angina Pectoris (Chest Pain): Ivabradine is also used for stable angina in patients with normal sinus rhythm who cannot tolerate or have contraindications to beta-blockers. It helps prevent angina attacks by reducing the heart rate, which in turn decreases the oxygen demand of the heart.

Mechanism of Action:

Ivabradine works by selectively inhibiting the If (funny) current in the sinoatrial node of the heart, which is responsible for controlling the heart rate. This results in a decrease in heart rate without affecting the heart's contractility or blood pressure.

Important Considerations:

• Heart Rate Monitoring: Ivabradine is typically prescribed for individuals with a heart rate that is too high. It is important to regularly monitor the heart rate while using this medication to avoid excessively low heart rates (bradycardia).
• Side Effects: Common side effects include visual disturbances (e.g., seeing halos or a brief light streak in the vision), headaches, and dizziness. These are generally mild and improve with time.
• Contraindications: Ivabradine should not be used in people with severe liver disease, heart block, or low blood pressure (hypotension). It is also not suitable for patients with sick sinus syndrome or atrial fibrillation.

Always follow the prescribed dosage and instructions from your healthcare provider, and report any unusual symptoms, especially related to heart rate or vision.