Care Global Pharmacy

Tofacitinib is used alone or together with other medicines (eg, DMARDs) to treat moderate to severely active rheumatoid arthritis, active psoriatic arthritis, ulcerative colitis, ankylosing spondylitis, and polyarticular course juvenile idiopathic arthritis (pcJIA) in patients who have taken other medicines

Durolane is a brand name for an injectable form of hyaluronic acid used primarily for joint pain and osteoarthritis management. The 20mg Durolane Injection contains a high concentration of hyaluronic acid, which is a substance naturally found in the body, particularly in the synovial fluid of the joints. It plays an important role in lubricating and cushioning the joints.

The 20mg Durolane Injection is typically used for the following conditions:

1. Osteoarthritis:

• Durolane is most commonly used for knee osteoarthritis (OA), but it may also be used for other joints affected by OA, such as the hip or shoulder.
• In OA, the cartilage in the joints wears away, causing pain, inflammation, and reduced mobility. Durolane works by providing lubrication and cushioning to the affected joint, helping to reduce pain and improve function.
• It is often used for people who do not respond to oral pain relievers (like NSAIDs) or physical therapy.

2. Joint Pain and Inflammation:

• Durolane injections may be recommended to reduce pain and inflammation in joints that are affected by degenerative conditions. It helps restore the natural properties of synovial fluid in the joint, leading to improved joint movement and reduced discomfort.

Mechanism of Action:

Durolane is a viscosupplementation treatment. The hyaluronic acid in Durolane acts as a lubricant and shock absorber, helping to restore the normal function of the synovial fluid in the joint. This alleviates pain, improves mobility, and reduces inflammation in people with osteoarthritis.

Dosage and Administration:

• Durolane is typically injected directly into the affected joint (e.g., knee, hip, or shoulder) by a healthcare provider. The 20mg dose may vary based on the severity of the condition and the joint being treated.
• In many cases, one injection is administered, with additional injections possible after several months if needed for continued symptom relief.

Benefits:

• Pain Relief: The injection helps relieve pain, allowing for better movement and quality of life.
• Improved Joint Function: By restoring lubrication, Durolane can improve joint function and reduce stiffness.

30g Tofatas Tofacitinib Ointment isused foratopic dermatitis(eczema) andalopecia areata(hair loss) by applying a thin layer to the affected area. To use, first clean and thoroughly dry the affected area, then gently rub a thin layer of the ointment into the skin until it's absorbed. It's crucial to only use it as directed by a doctor and avoid contact with eyes, mouth, or mucous membranes.

Other Tofacitinib Brands (Generics) in India:
Many generic versions of tofacitinib tablets are available in India: Tofajak Tablet(Cipla Ltd) Tofe Tablet(Alkem Laboratories Ltd) Intajac Tablet Betrecep Tablet Jakura Tablet Tofashine Tablet(Sun Pharmaceutical Industries Ltd) Tofaciz Tablet Tofadoz Tablet

Terifrac Solo 600mcg Injection is a man-made version of the parathyroid hormone used to treat men and postmenopausal women who have severe osteoporosis with a high risk of fractures. It works by stimulating new bone formation, which improves bone density and decreases the risk of spinal fractures.

Hyalgan Injection is a medicine used in the treatment of osteoarthritis of the knee in patients who have failed to respond adequately to conservative therapy and simple analgesics. It reduces the swelling and stiffness in the joints and improve joint function.

Hyalgan Injection is generally administered by a doctor or a nurse. You should not self-administer this medicine at home. The dosage will depend on the the age, weight, and clinical condition of the patient as well as laboratory determinations. Get the injection for as long as the doctor has prescribed even if you get better until that doctor tells you it is alright to stop.

Common side effects of this medicine include injection site reactions (such as swelling, pain, and redness), joint swelling, and pain in the joints. If the side effects get worse or bother you, or if you experience any other symptoms which you think are caused by this medicine, let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, let your doctor know of all the other medicines you are taking before using this medicine. If you are pregnant or breastfeeding, you should consult your doctor first before taking this medicine.

Mabura 40mg Injection contains methylprednisolone, a synthetic corticosteroid used to treat various conditions caused by inflammation and immune system dysfunction. It is part of a class of drugs known as steroidal anti-inflammatory drugs (SAIDs). Methylprednisolone works by suppressing inflammation and modifying the immune response. Here are the common uses for Mabura 40mg Injection:

Common Uses of Mabura 40mg Injection:

1. Inflammatory and Autoimmune Conditions:

   • Rheumatoid Arthritis: Mabura is used to treat the symptoms of rheumatoid arthritis, an autoimmune disease that causes joint inflammation, pain, and stiffness.
   • Systemic Lupus Erythematosus (SLE): It is used in the management of lupus, an autoimmune disorder where the body's immune system attacks its own tissues, leading to inflammation and organ damage.
   • Osteoarthritis: For individuals with severe inflammation in joints, Mabura may be used as part of a treatment plan to reduce pain and swelling.

2. Allergic Reactions:

   • Severe Allergies: Mabura is sometimes prescribed for severe allergic reactions, such as anaphylaxis or other acute allergic responses, to help control inflammation and prevent the immune system from overreacting.
   • Allergic Dermatitis and Skin Conditions: It can help manage allergic skin reactions and conditions like eczema or hives.

3. Respiratory Conditions:

   • Asthma: Mabura can be used in cases of severe asthma attacks to reduce airway inflammation and improve breathing.
   • Chronic Obstructive Pulmonary Disease (COPD): For acute flare-ups of COPD, which causes airflow obstruction and difficulty breathing, Mabura can help reduce inflammation in the airways.

4. Acute Inflammatory Conditions:

   • Inflammatory Bowel Disease (IBD): Conditions like Crohn’s disease and ulcerative colitis, which cause chronic inflammation in the digestive tract, may be treated with Mabura to control flare-ups.
   • Arthritis, Tendonitis, and Bursitis: Mabura can be used to treat the inflammation caused by various types of arthritis, tendonitis, and bursitis, helping to reduce pain and swelling in joints and surrounding tissues.

5. Adrenal Insufficiency:

   • Replacement Therapy: Mabura is sometimes used as a corticosteroid replacement therapy in patients with adrenal insufficiency (Addison’s disease), where the adrenal glands do not produce enough cortisol.

6. Neurological Conditions:

   • Multiple Sclerosis (MS): Mabura can be used to treat acute exacerbations of multiple sclerosis, an autoimmune disease affecting the nervous system, by reducing inflammation and swelling in the brain and spinal cord.
   • Spinal Cord Injury: In cases of spinal cord injury, Mabura may be used to reduce inflammation and prevent further damage to nerve cells.

7. Cancer Treatment (in some cases):

   • Chemotherapy Support: Mabura may be used in some cancer treatments to reduce inflammation, manage side effects, or suppress the immune system in cases where it is overactive, such as in certain cancers or post-surgical recovery.

Golimurel 50mg Injection contains an active component as Golimumab. It is a monoclonal antibody drug used to treat autoimmune diseases, particularly certain inflammatory conditions. It works by targeting and inhibiting a certain protein, which plays a role in causing inflammation in the body. It is used to treat moderate to severe rheumatoid arthritis in adults, often in combination with other disease-modifying antirheumatic drugs (DMARDs). It is also approved for treating psoriatic arthritis, an autoimmune condition affecting joints and skin. It can treat ankylosing spondylitis, a type of arthritis primarily affecting the spine and sacroiliac joints. One of the advantages of this medication is that it offers relatively long dosing intervals compared to other biological medications. 

Golimurel 50mg Injection should not be used in patients with known hypersensitivity or severe allergic reactions to the drug. Allergic reactions can be life-threatening and may include symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing. This medication can suppress the immune system, making patients more susceptible to infections. Individuals with active infections should start treatment once the infection is resolved. Individuals with a history of hepatitis B infection should require close monitoring before starting treatment, as the virus can reactivate during treatment. Patients with a history of heart failure or other significant cardiovascular conditions require close monitoring. Golimurel 50mg Injection's safety and efficacy in pediatric patients may differ from its use in adults. Older individuals may be at a higher risk of osteoporosis and fractures. The impact of this medication on bone health should be monitored, especially if the patient is already at risk. Patients with kidney impairment may require dose adjustments, as the clearance of these medications, is affected by impaired kidney function.