Care Global Pharmacy

Rybelsus (Semaglutide) 3mg Tablets contain semaglutide, a medication primarily used for the treatment of type 2 diabetes and, in some cases, for weight management. Semaglutide is a GLP-1 receptor agonist, meaning it mimics the action of a natural hormone called glucagon-like peptide-1 (GLP-1), which plays a role in regulating blood sugar levels, appetite, and insulin secretion.

Key Uses of Rybelsus (Semaglutide 3mg Tablets):

1. Management of Type 2 Diabetes:

   • Semaglutide is primarily prescribed to help control blood sugar levels in type 2 diabetes. It works by:
     • Stimulating the release of insulin in response to meals.
     • Reducing the amount of sugar produced by the liver.
     • Slowing down gastric emptying, which helps regulate blood sugar levels and prevents spikes after eating.
   • This medication is typically used in combination with diet and exercise and may be combined with other diabetes medications if needed.

2. Weight Management (Off-label or Additional Use):

   • Semaglutide has been shown to promote weight loss in people with obesity or overweight individuals. Although weight loss is not the primary indication for Rybelsus, some patients may experience significant weight reduction as a secondary benefit.
   • It can be prescribed off-label as part of a weight management program for patients with or without diabetes.

3. Reduction of Cardiovascular Risk in Type 2 Diabetes:

   • Studies have shown that semaglutide may help reduce the risk of major cardiovascular events (like heart attack or stroke) in individuals with type 2 diabetes who also have established cardiovascular disease (CVD).

Mechanism of Action:

• GLP-1 Receptor Agonism: Semaglutide works by activating GLP-1 receptors, which help regulate insulin release in response to meals, reduce glucagon secretion (which prevents the liver from producing too much sugar), and slow gastric emptying to promote satiety and prevent overeating.

Orligal (Orlistat) 120mg Capsules contain orlistat, a medication used to help with weight management by inhibiting the absorption of dietary fat. Orlistat works by blocking the action of enzymes called lipases, which are responsible for breaking down fat in the digestive system. As a result, approximately one-third of the fat you consume is not absorbed and is instead excreted in the stool.

Key Uses of Orligal (Orlistat 120mg Capsules):

1. Weight Loss Management:

   • Orlistat is used as a part of a weight-loss plan for overweight or obese individuals, typically when combined with a reduced-calorie diet and regular physical activity.
   • It helps people who are struggling with weight loss by reducing the amount of fat that is absorbed from food, thus contributing to overall calorie reduction.

2. Maintenance of Weight Loss:

   • After achieving weight loss, Orlistat can be continued to help maintain weight loss and prevent weight regain. It can help individuals adhere to a healthier diet by preventing the absorption of excess dietary fat.

3. Management of Obesity-Related Conditions:

   • Orlistat is often used in people with obesity and conditions related to obesity, such as type 2 diabetes, high blood pressure, or high cholesterol. Reducing weight with the help of Orlistat can help improve these conditions.

Mechanism of Action:

Orlistat works by inhibiting gastric and pancreatic lipases, enzymes that break down fat in the intestines. When these enzymes are blocked, about one-third of the fat consumed in food is not absorbed and is excreted in the stool.

Important Considerations:

• Dietary Adjustments: It is important to follow a balanced, low-fat diet while using Orlistat to minimize gastrointestinal side effects. A high-fat diet can increase the risk of unpleasant side effects like oily stools, flatulence, and diarrhea.
• Side Effects: Common side effects are primarily gastrointestinal and may include stomach pain, bloating, gas, and fatty or oily stools. These side effects typically occur when the individual consumes too much fat in their diet.
• Vitamin and Mineral Deficiency: Since Orlistat reduces fat absorption, it can also reduce the absorption of fat-soluble vitamins (A, D, E, and K). Taking a multivitamin supplement is often recommended.
• Liver Function: Orlistat has been associated with liver damage in rare cases. Regular monitoring of liver function may be necessary, especially during long-term use.
• Pregnancy and Breastfeeding: Orlistat should not be used during pregnancy, as it is intended for weight loss, which is not recommended during pregnancy. It is also advised to consult a doctor before using the medication while breastfeeding.

Orlistat is most effective when combined with a healthy, calorie-controlled diet and an exercise regimen. Always follow the prescribed dosage and consult with your healthcare provider before starting or discontinuing the medication.